Teneurins

Teneurins (TEN1-4) are a conserved family of transmembrane glycoproteins expressed during pattern formation and morphogenesis and are highly expressed in the brain. The large, conserved extracellular domain of all four teneurins is characterized by a series of EGF-like repeats, a 6-bladed beta-propeller followed by a YD-repeat barrel whereas the intracellular domain binds to the cytoskeleton and can be cleaved and transported to the nucleus, potentially acting as a transcription factor. ^{1 2 3 4}