Neuroligins

The family comprises four members (NLGN1-4) that function as postsynaptic components of the trans-synaptic neurexin-neuroligin complexes. Neuroligins function as cell-adhesion molecules that have important roles in the formation and function of synaptic structures. Structurally, the neuroligins is comprised of a single extracellular esterase-homology domain that self-associate, presenting the neuroligins as dimers on the cell surface. ^{1 2}