LRRTMs

Leucine-rich repeat transmembrane proteins (LRRTM1-4) are a family of synaptic cleft adhesion proteins that are involved in synaptic organization. The LRRTMs show a developmentally regulated expression in the neurons of different brain regions and have been suggested to play a role in neuronal development and maintenance. They belong to the Leucine-rich repeat superfamily of proteins and contain a single extracellular leucine-rich domain with 8-10 repeats. LRRTMs are known to interact with neurexins and heparan sulfate proteoglycans. ^{1 2}